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KMID : 0380519970010020107
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Korean Journal of Veterinary Pathology
1997 Volume.1 No. 2 p.107 ~ p.118
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A Study of Anticarcinogenic Effects of Allyl methyl Trisulfide and Methyl Propyl Disulfide on F344 Rats in a Rat Multi-organ Carcinogenesis Model
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Son Hwa-Young
Kang Boo-Hyon
Ha Chang-Su
Roh Jung-Koo
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Abstract
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The anticarcinogenic effects of allyl methyl trisulfide(AMT) and methyl propyl disulfide(MPD) were studied in a 28 weeks rat multi-organ carcinogenesis model. Tumor incidence rate was decreased by AMT or MPD treatment comparing with the positive control. AMT treatment significantly decreased the incidence of neoplastic and preneoplastic lesions in the kidney thyroid gland urinary bladder alimentary tract lung and Zymbal’s gland. MPD also inhibited incidence of noplastic and preneoplastic lesions in the liver kidney urinary bladder alimentary tract lung and Zymbal’s gland but increased that in the thyroid gland. GST-p positive foci in the liver were slightly decreased by AMT or MPD. There was no significant histopathological lesions in AMT or MPD treated group without pretreatment of carcinogens.
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KEYWORD
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Allyl methyl trisulfide, methyl propyl disulfide, multi-organ carcinogenesis model, F344 rat
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